Some users also report a subtle but real improvement in general vitality — likely a combination of IGF-1 effects and improved sleep architecture. GH and IGF-1 both stimulate collagen and elastin production. When it binds, the pituitary releases a pulse of growth hormone. Ipamorelin is a synthetic pentapeptide — a chain of just five amino acids — that mimics ghrelin and binds to the growth hormone secretagogue receptor 1a (GHS-R1a) in the pituitary gland. Ipamorelin became the benchmark for what a selective growth hormone secretagogue could look like. When I started, my provider assessed my testosterone alongside IGF-1 and found that my testosterone was limiting my GH response. The provider understood exactly how to integrate both — the testosterone was supporting IGF-1 production while the Sermorelin was optimizing GH pulsatility.
Even today after significant efforts to develop pharmaceutical strategies to mitigate muscle wasting (Sepulveda et al., 2015), contractile activity in the form of resistance exercise (RE) remains the most efficacious intervention. Skeletal muscle accounts for ~40–45% of total body mass (Romagnoli et al., 2020). For men struggling with low testosterone, our IGF-1 sprays, including our ultra-powerful Man’s Edge, can be a natural and effective solution to boost their hormonal health, muscle strength, and quality of life. Longjack, a traditional herbal remedy, complements this blend by further boosting testosterone levels, enhancing sexual health, and reducing fatigue. Fenugreek, renowned for its ability to naturally increase testosterone and libido, also supports metabolism and overall vitality. IGF-1, a natural growth factor, plays a critical role in muscle development and recovery, making it a cornerstone of this potent formula.
If I have high IGF-1, does that guarantee high testosterone? Attempting to artificially manipulate IGF-1 levels, particularly through exogenous administration, carries significant risks. Focusing solely on IGF-1 for testosterone optimization is misguided. Attempting to directly boost testosterone solely by focusing on increasing IGF-1 is not a reliable or recommended approach. The relationship between IGF-1 and testosterone is indirect and mediated through several pathways.
Because if estrogen is ignored, neither testosterone nor IGF-1 will deliver optimal results. The short answer is no—but the complete answer requires understanding how testosterone, IGF-1, and estrogen interact. Is IGF-1 more important than testosterone for building muscle and strength? Age-related declines in IGF-1 and testosterone can contribute to various health issues in men, including muscle loss, decreased bone density, fatigue, and reduced libido. How do age-related declines in IGF-1 and testosterone affect men’s health? What role does insulin play in the IGF-1 and testosterone relationship?
One directly affects the somatotropic cells of the anterior pituitary, itself inhibiting further release of GH, whilst the other affects GH releasing hormone and somatostatin release from the hypothalamus to reduce the secretion of GH. GH-induced IGF-1 released from the liver in response to RE is involved in two negative feedback loops. This implies that locally produced, autocrine/paracrine IGF-1 plays an important role in both pre- and postnatal growth. A liver-specific knockout mouse exhibited some postnatal growth reduction, but not as severe as with global IGF knockout (Baker et al., 1993; Tahimic et al., 2013). The exact mechanism of exercise-induced GH release remain ill-defined, however are likely driven via higher intensities of RE directly stimulating the anterior pituitary, facilitated via increasing circulating of catecholamines, lactate, nitric oxide and changes in acid-base balance (Godfrey et al., 2003).
In males rats, castration at 60–80 days of age decreases soma size while testosterone treatment of females increases soma size, but not to the extent seen in males (Breedlove and Arnold, 1981). These data also raise the question of "Which hormone(s) (or other circulating factors) exert effects on the motor system? Taken together, the data suggest the decline of circulating factors with aging may be a critical mechanism driving age-related alterations in the motor system. Thus, it is clear that with advancing age there is a plethora of form and function changes in the motoric system, and it is likely that these changes are linked to impairments in physical performance. Our recent findings also suggest an interrelationship between functioning motor unit number and muscle strength in older adults with a reduced number of estimated functioning motor units being related to muscle weakness (Kaya et al., 2013). Conversely, most human studies examining the effects of steroids on the nervous system have mostly examined cognitive outcomes without particular emphasis on the motor system or physical function and/or strength. However, data from animals demonstrate that administering either testosterone or IGF-1 to cells of the central and peripheral motor system can increase cell excitability, attenuate atrophic changes, and improve regenerative capacity of motor neurons.
— There are many factors that can affect synthesis and circulation of hormone levels, including body composition, sleep rhythm, nutritional status, and energy balance. Cellular response to testosterone-AR signaling may involve inhibition of the expression of myostatin, which is a negative regulator of SC's proliferation and an inhibitor of muscle growth. The GH/IGF-1 axis, is part of the HPS-axis and is a key system involved in psychobioMACHINE’s ability to adapt to exercise via hypertrophy of skeletal muscle, especially in response to exercise induced muscle damage. Hormone, resistance exercise, muscle growth, protein synthesis, hypertrophy Lower levels of these anabolic hormones in older adults induces anabolic resistance during RE which may partially explain their low sensitivity to a given anabolic stimulus.

Rayford Boshears, 20 years

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